Lyme Disease Diagnosis
Laboratory support for a clinical diagnosis of chronic Lyme disease is currently provided by positive results in various antigen, antibody and/or molecular based assays for Borrelia burgdorferi. Inter-laboratory variability in the performance, reading and interpretation of Lyme disease testing has thrown into question the reliability of such assays, even to the extent that the clinical diagnosis is not infrequently sustained even in the face of negative or inconsistent laboratory findings. Conversely, over time, many patients already diagnosed as having Lyme disease on the basis of positive serological tests are now revealing additional positive assays to such diverse infectious agents as Babesia, Ehrlichiosis, Mycoplasma, Chlamydia, human herpesvirus-6, parvo virus, etc.
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