Brain Magnetic Resonance Imaging Does Not Contribute to the Diagnosis of Chronic Neuroborreliosis. A

 Acta Radiologica, Volume 48, Issue 7 2007 , pages 755 - 762  Brain Magnetic Resonance 
Imaging Does Not Contribute to the Diagnosis of Chronic Neuroborreliosis.  Aalto A, Sjöwall J, 
Davidsson L, Forsberg P, Smedby O. Division of Radiology, Department of Medicine and Care, 
Faculty of Health Sciences, Linköping University, Linköping, Sweden. anne.aalto@imv.liu.se
BACKGROUND: Borrelia infections, especially chronic neuroborreliosis, NB, may cause 
considerable diagnostic problems. This diagnosis is based on symptoms and findings in the 
cerebrospinal fluid but is not always conclusive. PURPOSE: To evaluate brain magnetic 
resonance imaging, MRI, in chronic NB, to compare the findings with healthy controls, and to 
correlate MRI findings with disease duration. MATERIAL AND METHODS: Sixteen 
well-characterized patients with chronic NB and 16 matched controls were examined in a 1.5T 
scanner with a standard head coil. T1-, with and without gadolinium, T2-, and 
diffusion-weighted imaging plus fluid-attenuated inversion recovery, FLAIR, imaging were used. 
RESULTS: White matter lesions and lesions in the basal ganglia were seen in 12 patients and 10 
controls, no significant difference. Subependymal lesions were detected in patients down to the 
68age of 25 and in the controls down to the age of 43. The number of lesions was correlated to age 
both in patients, rho = 0.83, P<0.01, and in controls, rho = 0.61, P<0.05, but not to the duration of 
disease. Most lesions were detected with FLAIR, but many also with T2-weighted imaging. 
CONCLUSION: A number of MRI findings were detected in patients with chronic NB, 
although the findings were unspecific when compared with matched controls and did not 
correlate with disease duration




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