Comparison of oral cefixime and intravenous ceftriaxone followed by oral amoxicillin in disseminated Lyme borreliosis.

 Eur J Clin Microbiol Infect Dis. 1998 Oct;17,10:715-9.Comparison of oral cefixime and 
intravenous ceftriaxone followed by oral amoxicillin in disseminated Lyme borreliosis. Oksi J, 
Nikoskelainen J, Viljanen MK. Department of Medicine, Turku University Central Hospital, 
Finland.
Two treatment regimens for disseminated Lyme borreliosis, mainly neurologic and 
musculoskeletal manifestations, were compared in a randomized trial. A group of 30 patients 
received oral cefixime 200 mg combined with probenecid 500 mg three times daily for 100 days. 
Another group of 30 patients received intravenous ceftriaxone 2 g daily for 14 days followed by 
oral amoxicillin 500 mg combined with probenecid 500 mg three times daily for 100 days. There 
was no statistically significant difference in the outcome of infection between the two groups. 
However, the total number of patients with relapses or no response at all and the number of 
positive polymerase chain reaction findings after therapy were greater in the cefixime group. The 
general outcomes of infection in patients with disseminated Lyme borreliosis after 3-4 months of 
therapy indicate that prolonged courses of antibiotics may be beneficial in this setting, since 
90% of the patients showed excellent or good treatment responses




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