Concentration of soluble forms of selectins in serum and in cerebrospinal fluid in group of patients with neuroborreliosis

 Pol Merkur Lekarski. 2007 Sep;23,135:174-8. Concentration of soluble forms of selectins
in serum and in cerebrospinal fluid in group of patients with neuroborreliosis--a preliminary 
study Moniuszko AM, Pancewicz SA, Ko ndrusik M, Zajkowska J, Grygorczuk S, Swierzbi·ska R. 
Akademia Medyczna w Bia·ymstoku, Klinika Chorób Zaka·nych i Neuroinfekcji.
The results of the research already done, suggest an important role of selectins in inflammatory 
process of various etiology. Lack of selectins or their ligands causes severe complications, such as 
chronic inflammatory processes. The aim of this study was to analyze the role of selectins sL, sE
and sP in the development and course of neuroborreliosis in the form of meningitis. We have also 
analyzed the influence of treatment on changes of selectins' concentration in serum and 
cerebrospinal fluid. MATERIAL AND METHODS: We have analyzed 17 patients with 
neuroborreliosis presenting as meningitis, in whom we measured by immunoenzymatic method 
concentration of selectins sL, sP and sE in blood and cerebrospinal fluid before and after 4-week 
therapy with cefotaxim. We used Human sL-selectin, Human sE-selectin and Human sP-selectin
kits produced by Bender Med. Systems, Austria. Control group for measurement of 
concentration of selectins in serum consisted of 8 healthy patients. Control group for 
measurement of concentration of selectins in cerebrospinal fluid consisted of 8 patients, in whom 
lumbar puncture excluded inflammatory disease of the central nervous system. RESULTS: In 
serum concentration of selectins sL and sP was significantly higher comparing to control group. 
After treatment concentration of these selectins decreased, but still was significantly higher than 
in control group. Only con centration of selectin sE was significantly lower than in control group 
and after treatment decreased further remaining lower comparing to control group. In 
71cerebrospinal fluid concentration of selectin sL was significantly higher comparing to control 
group and increased after treatment. Concentration of selectins sE and sP increased before 
treatment and decreased after treatment, but still remained elevated comparing to control group. 
CONCLUSIONS: Persistence of increased concentration of selectins sP and sL in serum and 
also of selectin sE in cerebrospinal fluid in patients with neuroborreliosis after completed 
antibiotic therapy and regression of clinical symptoms can suggest permanence of chronic 
inflammatory state in consequence of survival of B. burgdorferi spirochetes in affected 
tissues




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