Concentrations of pro-inflammatory cytokines IFN-gamma,

 Pol Merkur Lekarski. 2007 Apr;22,130:275-9. Related Articles, Concentrations of 
pro-inflammatory cytokines IFN-gamma, IL-6, IL-12 and IL-15 in serum and cerebrospinal 
fluid in patients with neuroborreliosis undergoing antibiotic treatment. Article in Polish. 
Pancewicz SA, Kondrusik M, Zajkowska J, Grygorczuk S. Akademia Medyczna w Bialymstoku, 
Klinika ChorÃ3b Zakaznych i Neuroinfekcji.20spancewicz@interia.pl
Pathogenesis of Lyme disease, including neuroborreliosis, remains unclear. However, 
pro-inflammatory cytokines seem to be involved and might be used to monitor the course of the 
disease. It has been also shown that B. burgdorferi protects itself from elimination by modulating 
function of the host's immune system. THE AIM OF THIS STUDY: The purpose of this study 
was to evaluate the serum and cerebrospinal fluid, CSF, concentrations of selected cytokines in 
patients with neuroborreliosis and their change during antibiotic treatment. MATERIAL AND 
METHODS: The group of 25 patients was examined, all undergoing antibiotic therapy due to 
meningitis caused by Borrelia burgdorferi infection. The group included 10, 40%, females and 15, 
60%, males in the mean age x = 42,3 years. The control group for serum measurements consisted 
of 25 healthy individuals, mean age x =43, 1, while control group for CSF study included 10 
patients, aged x = 53,5 years, from whom CSF with normal parameters was taken during 
diagnostic procedures neurosurgical. We examined serum and CSF before and after antibiotics 
for concentrations of interferon-gamma, INF-gamma, interleukin-6, IL-6, interleukin-12, IL-12, 
and interleukin-15, IL-15. RESULTS: In the first examination the significant increase of 
IFN-gamma, IL-6, IL-2, IL-15 serum and CSF concentration was detected in comparison to 
control group. After 4-weeks antibiotic treatment the concentrations of studied cytokines
decreased significantly in serum as well as in CSF but remained increased in compa rison with 
controls. CONCLUSIONS: Although antibiotic treatment leads to withdrawal of clinical 
symptoms of neuroborreliosis and normalization of CSF general parameters, pro-inflammatory 
cytokines' concentrations in serum and CSF remain elevated.It may be explained by the 
persistence of inflammatory conditions, perhaps related to surviving of a fraction of Borrelia
burgdorferi spirochetes within CNS tissue. This phenomenon might lead to development of 
chronic CNS lesions




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