Eucaryotic cells protect Borrelia burgdorferi from the action of penicillin and ceftriaxone but not from the action of 44doxycycline and erythromycin.

 Antimicrob Agents Chemother. 1996 Jun;40,6:1552-4. Eucaryotic cells protect Borrelia
burgdorferi from the action of penicillin and ceftriaxone but not from the action of 
44doxycycline and erythromycin. Brouqui P, Badiaga S, Raoult D. Unité des Rickettsies, Faculté de 
Médecine, Centre National de la Recherche Scientifique, Marseille, France.
Despite appropriate antibiotic treatment, Lyme disease patients may have relapses or may 
develop chronic manifestations. The intracellular location of Borrelia burgdorferi suggests that 
antibiotics that penetrate cells will have greater efficiency. Doxycycline or erythromycin was more 
effective than penicillin or ceftriaxone in killing B. burgdorferi when the organism was grown in 
the presence of eucaryotic cell




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