First isolation of Borrelia burgdorferi from an iris biopsy.

 J Clin Neuroophthalmol. 1993 Sep;13,3:155-61; discussion 162. 59: First isolation of Borrelia
burgdorferi from an iris biopsy. Preac-Mursic V, Pfister HW, Spiegel H, Burk R, Wilske B, 
Reinhardt S, Böhmer R.
30Max v. Pettenkofer Institut für Hygiene u. Medizinische Mikrobiologie, LM-Universität
München, Germany.
The persistence of Borrelia burgdorferi in six patients is described. Borrelia burgdorferi has 
been cultivated from iris biopsy, skin biopsy, and cerebrospinal fluid also after antibiotic therapy 
for Lyme borreliosis. Lyme Serology: IgG antibodies to B. burgdorferi were positive, IgM
negative in four patients; in two patients both IgM and IgG were negative. Antibiotic therapy may 
abrogate the antibody response to the infection as shown by our results. Patients may have 
subclinical or clinical disease without diagnostic antibody titers. Persistence of B. burgdorferi
cannot be excluded when the serum is negative for antibodies against it
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