In vitro susceptibility of isolates of Borrelia burgdorferi

 Int J Immunopathol Pharmacol. 2006 Jul-Sep;19,3:545-9. In vitro susceptibility of isolates of 
Borrelia burgdorferi s.l. to antimicrobial agents. Santino I, Scazzocchio F, Ciceroni L, 
Ciarrocchi S, Sessa R, Del Piano M. Department of Public Health Sciences, La Sapienza
University, Rome, Italy. iolanda.santino@uniroma1.it
In the present study, we investigate the in vitro antimicrobial activity of macrolides, 
beta-lactams and tetracycline against Borrelia burgdorferi s.l. clinical and tick isolates. 
Minimal inhibitory concentrations, MICs, were determined in normal growth condition and after 
pre-exposure of the strains to sub-MIC of the founder of each drug family. All the classes of 
tested antibiotics showed good antibacterial activity against all the borreliae isolates and there 
were no significant susceptibility differences among clinical and tick isolates. After pre-exposure 
of the strains to sub-MIC of erythromycin, cefoxitin and tetracycline, we observed that some 
strains of B. burgdorferi s.l. showed higher MIC values to both the pre-exposed drug and 
drugs of the same family. The less susceptibility of borreliae, in the last growth condition in 
vitro, could be one of the justifications of clinical results indicating the limited efficacy of 
these antibiotics in treatment of B. burgdoferi infections




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