Kill kinetics of Borrelia burgdorferi and bacterial findings in relation to the treatment of Lyme borreliosis.

 Infection. 1996 Jan-Feb;24,1:9-16. Erratum in: Infection 1996 Mar-Apr;24,2:169.Kill 
kinetics of Borrelia burgdorferi and bacterial findings in relation to the treatment of Lyme 
borreliosis. Preac Mursic V, Marget W, Busch U, Pleterski Rigler D, Hagl S. Max v. Pettenkofer
Institut, Ludwig-Maximilians-Universität München, Germany.
For a better understanding of the persistence of Borrelia burgdorferi sensu lato, s.l., after 
antibiotic therapy the kinetics of killing B. burgdorferi s.l. under amoxicillin, doxycycline, 
cefotaxime, ceftriaxone, azithromycin and penicillin G were determined.The killing effect was 
investigated in MKP medium and human serum during a 72 h exposure to antibiotics. Twenty 
clinical isolates were used, including ten strains of Borrelia afzelii and ten strains of Borrelia
garinii. The results show that the kinetics of killing borreliae differ from antibiotic to antibiotic. 
The killing rate of a given antibiotic is less dependent on the concentration of the antibiotic than 
on the reaction time. Furthermore , the data show that the strains of B. afzelii and B. garinii have 
a different reaction to antibiotics used in the treatment of Lyme borreliosis and that different 
reactions to given antibiotics also exist within one species.The B. garinii strains appear to be 
42more sensitive to antibiotics used in therapy. Furthermore, the persistence of B. burgdorferi
s.l. and clinical recurrences in patients despite seemingly adequate antibiotic treatment is 
described. The patients had clinical disease with or without diagnostic antibody titers to B. 
burgdorferi




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