migration of Borrelia burgdorferi in tissues and persistence after antibiotic treatment.

 Journal of Spirochetal & Tick-borne Diseases, Vol. 4, No. 1/2 Two lessons from the canine 
model of Lyme Disease: migration of Borrelia burgdorferi in tissues and persistence after 
antibiotic treatment. Straubinger RK; 1997 Straubinger AF; Jacobson RH; Chang Y; Summer 
BA;
[Persistence:] In two studies, antibiotic treatment with amoxicillin or doxycycline for 30 days 
failed to eliminate persistent infection in 11 dogs. Immediately after treatment, borreliae could 
not be demonstrated, antibody levels declined, and joint lesions were prevented or cured. Live 
spirochetes, however, persisted in the tissue of at least three dogs as B. burgdorferi DNA was 
detected in all 11 treated dogs for up to 6 months after treatment, at which time antibody levels 
again began to rise.
[Diagnostic issues:] In the dog model, we detected B. burgdorferi reliably in skin but infrequently 
in blood by culture and polymerase chain reaction, PCR. We found the organism in the 
synovium of joints but not in synovial fluids, and in meninges but not in cerebrospinal fluid.




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