Persistent PCR positivity in a patient being treated for Lyme disease.

 Persistent PCR positivity in a patient being treated for Lyme disease. Kornelia Keszler, MD 
and Richard C. Tilton, PhD. JSTD 1995; 2:57-58.
A 30-year-old white female presented with worsening clinical symptoms suggestive of Lyme 
disease while on antibiotic therapy. Results of enzyme-linked immunosorbent assay, ELISA, and 
of western blot tests for IgG and IgM antibody were equivocal. However, Borrelia burgdorferi
DNA detected by the polymerase chain reaction, PCR, was detected in whole blood on two 
separate occasions, 1 month apart, while the patient was on oral doxycycline, 100 mg b.i.d. 
This report questions the significance of persistent Borrelia burgdorferi DNA in a patient who is 
not responding to antibiotic therapy




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