Seronegative Lyme arthritis. Holl-Wieden A, Suerbaum S, Girschick HJ. Children’s hospital, Section of Pediatric Rheumatology, Immunology and Infectious diseases, University of Wuerzburg,

 Rheumatol Int. 2007 Sep;27,11:1091-3. Epub 2007 Apr 4.  Seronegative Lyme arthritis.
Holl-Wieden A, Suerbaum S, Girschick HJ. Children's hospital, Section of Pediatric 
Rheumatology, Immunology and Infectious diseases, University of Wuerzburg, 
Josef-Schneider-Str. 2, 97090 Wuerzburg, Germany.
We present a 10-year-old girl who had been diagnosed with juvenile idiopathic arthritis 5 years 
before and who experienced a flare of arthritis affecting one knee while she was off medication 
for almost 3 years. Seronegative Lyme arthritis had to be diagnosed based on the detection of 
Borrelia burgdorferi DNA in synovial fluid. No humoral immune response to Borrelia
burgdorferi was detectable before, at the time of diagnosis and up to 3 years later




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