With recognition of chronic persistent infection, we will begin to look at disease pathogenesis quite differently.

 Borrelia burgdorferi - Seek and ye shall find. Expanding the envelope Kenneth Liegner, 
MD. JSTD 1994; 1:79-81.
With recognition of chronic persistent infection, we will begin to look at disease pathogenesis 
quite differently. A persisting pathogen may induce noxious injure over not just days, weeks, 
or months, but years and decases and even the naturel life of the host. Slowly simmering 
infection can induce a wide variety of host responses, both directly and immune mediated. The 
treatment approach may need to be very different in this circumstance than for a readily 
extirpated bacterium such as staphylococcus or streptococcus. Chronic infection may require 
chronic treatment. Definitive cure, while theoretically possible, may not be achieved using 
currently available methods in chronically infected patients. This dilemma should prompt a 
determined effort to develop definitive means of curing the infection. We will begin to perceive 
just how daunting an adversary the borreliae really are how commonly affected the populace 
of endemic regions. Borrelia are resilient




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