CD 57 Test

CD 57

CD 57 Test

Here is a great article by Ginger Savely RN, FNP-C explaining the CD 57 and how it can be used for Lyme patients.

In Dr. Burrascano’s Treatment guidelines (I highly recommend that all Lyme patients print this 34 page manual): on page 8 it explains the CD57 as follows.

“Our ability to measure CD-57 represents a breakthrough in LB diagnosis and treatment. Chronic LB infections are known to suppress the immune system and decrease the quantity of the CD-57 subset of natural killer cells. As in HIV infection, where abnormally low T-cell counts are routinely used as a marker of how active that infection is, in LB we can use the degree of decrease of the CD-57 count to indicate how active the Lyme infection is and whether, after treatment ends, a relapse is likely to occur. It can even be used as a simple inexpensive screening test, because at this point we believe that only Borrelia (Lyme bacteria) will depress the CD-57. Thus a sick patient with a high CD-57 is probably ill with something other than Lyme, such as co-infections.

When the test is run by Labcorp (preferred lab) we want our Lyme patients to test above 60; a normal count is above 200. There generally is some degree of fluctuation of this count over time and the number does not progressively increase as treatment proceeds. Instead it will remain low until the LB infection is controlled and then it will jump. If the CD-57 count is not in the normal range when a course of antibiotics is ended, then a relapse will almost certainly occur.”

The CD-57 can be ordered by your doctor through Labcorp using the following info: 505026 HNK1 (CD57)Panel

The range of normal on this test is 60-360. Testing low on this test or below 60 indicates very likely active Lyme Disease. As a Lyme patient we “shoot” for 200 before stopping antibiotics (and of course remission of all symptoms for 4 full months) meaning our subset of natural killer cells (part of our immune system related to Lyme) are strong and healthy and fighting.

A CD57 can be used as a screening test, but only “works” only if it is low. If a CD57 comes back within normal range, it does no rule out Lyme Disease and co-infections. If symptomatic it is always wise to follow up this test with Igenex testing and then still base treatment on symptoms since no test is 100% reliable.

For an excellent explanation of the CD-57 read page 8 of the August 2006 issue of Public Health Alert for “All you wanted to know about the CD-57” : … pdf#page=8

Also see Dr. Burrascano’s CD57 table on page 6: … me2007.pdf

(taken from )

6 thoughts on “CD 57”

  1. All my tests are negative as well but my CD 57 was 7. But my LLMD decided to wait 6 weeks for further testing to see if my adrenals start functioning a bit better before starting treatment. I’m so frustrated and cant get a definitive answer.

  2. My CD 57 is a 9. I feel like death. My Lyme titers were negative. No one knows what is wrong with me. 😪

    1. My Lyme titers are negative and mine is 14. You have Lyme and when you immune system is this bad you can’t put forth a response to the infection by producing antibodies. You are too weak to make any IG and you will therefor come back negative when you have Lyme as bad as you do

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