Destruction of 80spirochete Borrelia burgdorferi round-body propagules

 Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18656-61. Epub 2009 Oct 20. Destruction of 
80spirochete Borrelia burgdorferi round-body propagules (RBs) by the antibiotic tigecycline. 
Brorson Ø, Brorson SH, Scythes J, MacAllister J, Wier A, Margulis L.
Department of Microbiology, Sentralsykehuset i Vestfold HF, N-3116 Tonsberg, Norway.
Persistence of tissue spirochetes of Borrelia burgdorferi as helices and round bodies (RBs) 
explains many erythema-Lyme disease symptoms. Spirochete RBs (reproductive propagules also 
called coccoid bodies, globular bodies, spherical bodies, granules, cysts, L-forms, sphaeroplasts, or 
vesicles) are induced by environmental conditions unfavorable for growth. Viable, they grow, 
move and reversibly convert into motile helices. Reversible pleiomorphy was recorded in at least 
six spirochete genera (>12 species). Penicillin solution is one unfavorable condition that induces 
RBs. This antibiotic that inhibits bacterial cell wall synthesis cures neither the second "Great 
Imitator" (Lyme borreliosis) nor the first: syphilis. Molecular-microscopic techniques, in 
principle, can detect in animals (insects, ticks, and mammals, including patients) helices and RBs
of live spirochetes. Genome sequences of B. burgdorferi and Treponema pallidum spirochetes 
show absence of >75% of genes in comparison with their free-living relatives. Irreversible 
integration of spirochetes at behavioral, metabolic, gene product and genetic levels into animal 
tissue has been documented. Irreversible integration of spirochetes may severely impair 
immunological response such that they persist undetected in tissue. We report in vitro inhibition 
and destruction of B. burgdorferi (helices, RBs = "cysts") by the antibiotic Tigecycline (TG; 
Wyeth), a glycylcycline protein-synthesis inhibitor (of both 30S and 70S ribosome subunits). 
Studies of the pleiomorphic life history stages in response to TG of both B. burgdorferi and 
Treponema pallidum in vivo and in vitro are strongly encouraged

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