Persistence of Borrelia burgdorferi sensu lato in patients with Lyme borreliosis

 Epidemiol Mikrobiol Imunol. 2001 Feb;50,1:10-6.Persistence of Borrelia burgdorferi sensu 
lato in patients with Lyme borreliosis [Article in Czech] Honegr K, Hulínská D, Dostál V, 
Gebouský P, Hanková E, Horácek J, Vyslouzil L, Havlasová J. Infekcní klinika, Fakultní
nemocnice, Hradec Králové.
59In 18 patients with Lyme borreliosis the authors proved the persistence of Borrelia
burgdorferi sensu lato by detection of the causal agent by immune electron microscopy or of 
its DNA by PCR in plasma or cerebrospinal fluid after an interval of 4-68 months. Clinical 
manifestations common in Lyme borreliosis were present in only half the patients, in the 
remainder non-specific symptoms were found. In nine subjects with confirmed Borrelia
burgdorferi sensu lato in the cerebrospinal fluid the cytological and biochemical finding was 
normal. Examination of antibodies by the ELISA method was negative in 7 of 18 patients during 
the first examination and in 12 of 18 during the second examination. In all negative examinations 
the specific antibodies were assessed by the Western blot or ELISA method after liberation from 
the immunocomplexes. In the authors' opinion it is advisable to examine repeatedly plasma and 
other biological material from potentially affected organs by PCR and subjects with persisting or 
relapsing complaints after the acute form of Lyme borreliosis as well as to examine cerebrospinal 
fluid in case on non-specific symptoms and concurrent pathic EEG or MR finding

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