Seronegative chronic relapsing neuroborreliosis

 Eur Neurol. 1995;35,2:113-7. Comment in: Eur Neurol. 1996;36,6:394-5. Seronegative 
chronic relapsing neuroborreliosis.Lawrence C, Lipton RB, Lowy FD, Coyle PK.
Department of Medicine, Albert Einstein College of Medicine, New York, N.Y., USA.
We report an unusual patient with evidence of Borrelia burgdorferi infection who 
experienced repeated neurologic relapses despite aggressive antibiotic therapy. Each course of 
therapy was associated with a Jarisch-Herxheimer-like reaction. Although the patient never had 
detectable free antibodies to B. burgdorferi in serum or spinal fluid, the CSF was positive on 
multiple occasions for complexed anti-B. burgdorferi antibodies, B. burgdorferi nucleic acids 
and free antigen

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